SUMMARY Cancer cells accumulate detrimental genetic mutations that perturb the function of important proteins they express. The Karras lab investigates how protein-folding chaperones, specialized proteins that help other proteins to fold and function within the cell, influence the accumulation and phenotypic manifestations of cancer mutations. We are looking for graduate trainees and postdocs with expertise in bioinformatics. Previous training in multiomics and yeast genetics is preferred.
Function: Provides responsible technical assistance in support of research projects by completing assignments requiring a basic knowledge of fundamental techniques and practices related to a particular field of academics or research.
Scope: Impacts cancer research efforts throughout the institution.
• Courtesy: Is respectful and courteous to each other at all times • Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; Is sensitive to the concerns of our patients and our co-workers
• Reliability: Communicates frequently, honestly and openly • Accountability: Holds self and others accountable for practicing our values • Safety: Notices a safety concern and brings it to someone’s attention; Models safe behaviors (wears badge, washes hands, keeps work area clean and orderly); Mitigates risk to the institution through sound business practices
• Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas • Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so
• Assists principal investigator with scientific research projects focused on understanding the impact of protein-folding chaperones on the accumulation of genetic variation and how they relate to evolution and cell function. • Functions, under supervision, in the design and initiation of research experiments. These experiments include, but are not limited to, genetic engineering of yeast and cancer cell lines, assessment of cellular drug tolerance in culture, chemical genetics, cloning plasmid DNA libraries for high-throughput assays, RT-PCR, Western blotting, immunohistochemistry, protein purification, proteomics, metabolomics, and other multi-omics approaches. • Performs bioinformatic analyses of next-generation DNA and RNA sequencing data to infer expression, gene copy number variation and perform de novo genome assembly. • Executes data integration pipelines and statistical analyses. • Assists in training and research work activity for assigned laboratory and research personnel. • Supervises general laboratory management including the assembly and use of laboratory equipment and implements safety procedures. Assists with basic laboratory techniques and in preparation of media solutions, buffers and reagents. • Reads literature and confers with superiors regarding new procedures and modifies them according to the needs of the project.
CORE COMPETENCIES • IC – Analytical Thinking: o Gather relevant information systematically; o Break down problems into simple components; and o Make sound decisions. • IC – Build Relationships: o Initiate, develop, and manage relationships and networks; and o Show sincere interest in others and their concerns. • IC – Innovative Thinking: o Approach problems with curiosity and open-mindedness; and o Offer new ideas, solutions and/or options.
Required: BS Biological Sciences or related field
Preferred: MS Bioinformatics
Received: Laboratory Principal Investigator or designee
About The University of Texas MD Anderson Cancer Center
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.